By Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette (auth.), Donald M. Wieland, Michael C. Tobes, Thomas J. Manger (eds.)
In 1906, Michael T. candy first constructed the chromatographic approach by utilizing an adsorbant to split pigments. due to the fact that that point, the technological advances in TLC and HPLC have caused new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is mainly depending on the chromat ographic approach a result of really small quantity of fabric in such a lot radiopharmaceuticals-often so small that the standard actual tools of analytical chemistry can't be used. hence, this number of papers represents the most important to winning radiopharmaceutical improvement by means of atmosphere the normal for the pres of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics affiliate Director The Squibb Institute for scientific learn New Brunswick, New Jersey Preface The chapters herein are up-to-date and multiplied types of displays that the authors made at a symposium hung on June four, 1984 in l. a., California lower than the sponsorship of the Radiopharmaceutical technology Council of the Society of Nuclear drugs. All manuscripts have been refereed. The motive of the symposium organizers was once to enlist individuals who paintings on a daily foundation with the analytical and chromatographic thoughts to be mentioned on the symposium. We consider convinced that this distillation of hands-on adventure could be of price to graduate scholars in addition to skilled researchers in radio pharmaceutical chemistry and comparable fields which use radiotracer methodology.
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Extra info for Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry
Chromatogr. Sci. 23:320-324, 1985. , Khatib, S. : Comparison of methods for separating polcyclic aromatic hydrocarbons by high performance thin-layer chromatography. 1. Chromatogr. 302:149-158, 1984. , Zlatkis, A. : Simultaneous determination of antiarrhythmia drugs by high performance thin-layer chromatography. 1. Chromatogr. 158:403-410, 1978. , Albert, D. : Calibration in TLC/HPTLC using Michaelis-Menten function. Chromatographia 18:23-27, 1984. , Santi, W. : Data-pair technique, a new approach to quantitative thin-layer chromatography.
This chapter covers the use of ITLC (instant thin-layer chromatography), TLC, mini-column and electrophoretic separation methods in radiopharmaceutical analyses, with particular emphasis on applications to 99ffiTc-based radiopharmaceuticals. A review is given of some, but by no means all, of the literature in these areas, along with a discussion of the use of these techniques in the radiopharmaceutical laboratories at Dupont-NEN Products. It is not my intention to cover radio-HPLC because it is reviewed elsewhere in this volume.
Scan rate Vl t: o C. ,(J) (J) Cl o 1 2 3 4 5 6 7 8 9 Distance (em) FIG. 2. Phantom design and example calibration scan. from radiochemical impurities in the sample is very good for a development distance of 10 cm, however, even shorter plate lengths may be used with adequate resolution for quantitation of the 99mTc complex of interest. 4 for the separation of a 99mTc(dmpehCli sample containing higher levels of radiochemical impurities using ~6 cm microscope slide TLC plates.
Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry by Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette (auth.), Donald M. Wieland, Michael C. Tobes, Thomas J. Manger (eds.)